3-(ETHOXYCARBONYL)-2-METHYLPYRROLE-5-CARBOXALDEHYDE AS A VERSATILE SYNTHONE FOR POTENTIAL ANTIBACTERIAL AGENTS

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt

2 Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt

3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Abstract

Reaction of 3-(ethoxycarbonyl)-2-methylpyrrole-5-carboxaldehyde with substituted thiosemicarbazides afforded the corresponding (thiocarbamoyl) hydrazones. The latter compounds underwent cyclization to thiazole, thiazolidinone, thiazinone and thiadizole derivatives under the proper reaction condition. All the prepared compounds were evaluated for this antimicrobial activity.
Bulletin of Pharmaceutical Sciences Assiut University
Volume 18, Issue 2
December 1995
Pages 59-67

Files

Share

How to cite

Statistics