DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES

Hassan, Hoda Y.; El-Shorbagi, Abdel-Nasser A.; El-Koussi, Nawal A.; Abdel-Zaher, Ahmed O.

doi:10.21608/bfsa.1994.69785

DESIGN AND SYNTHESIS OF' SOME NEW 1H-1,2,4-TRIAZOLES OF POTENTIAL ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES

Document Type : Original Article

Authors

¹ Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt

² Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71515, Egypt

³ Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

10.21608/bfsa.1994.69785

Abstract

The synthesized 1H-1,2,4-triazoles (7a-c, 8a-c and 9a-c), a novel class of heterocyclic compounds of potential anti-inflammatory and analgesic activities, are of interest, since they present some differences compared to the classical non-steroidal anti-inflammatory agents. The anti-inflammatory activity of all derivatives was studied in albino rats using trypan-blue and kaolin-induced edema methods. The compounds were also tested in albino mice for their analgesic activity using the hot plate and p-benzoquinone-induced writhing methods. A correlation between the structures, pharmacological actions and the calculated partition coefficients of the products was studied.