Lyophilization technique has been adopted to enhance the aqueous solubility of diazepam. Two hydrophilic polymers namely; polyvinyl pyrrolidone 44000 (PVP) and pluronic F-127 (PF-127) in different ratios were used as the adjuvents in preparing the freeze-dried samples. Of the tested ratios, diazepam: PVP (1:10) and diazepam: PF-127 (1:60) were found to gave the highest solubility of the drug. The dissolution studies revealed that lyophilized diazepam samples required from 1-3 minutes to dissolve compared to 20 minutes in case of untreated drug. Histological evaluations were performed after S.C. and I.M. injection into mice. A slight histological changes were induced. Consequently, the prepared lyophilized-diazepam product can be reconstituted with ease using phosphate buffer (pH 7.2) for parenteral administration, as well as it can met the requirement of zydis.
El-Harras, S., Shawky, S., Hafez, E., & Shaker, S. (1994). PHARMACEUTICAL AND HISTOLOGICAL STUDIES OF NEW SOLUBLE DIAZEPAM. Bulletin of Pharmaceutical Sciences Assiut University, 17(1), 73-79. doi: 10.21608/bfsa.1994.69790
MLA
S. A. El-Harras; S. Shawky; E. Hafez; S. Shaker. "PHARMACEUTICAL AND HISTOLOGICAL STUDIES OF NEW SOLUBLE DIAZEPAM". Bulletin of Pharmaceutical Sciences Assiut University, 17, 1, 1994, 73-79. doi: 10.21608/bfsa.1994.69790
HARVARD
El-Harras, S., Shawky, S., Hafez, E., Shaker, S. (1994). 'PHARMACEUTICAL AND HISTOLOGICAL STUDIES OF NEW SOLUBLE DIAZEPAM', Bulletin of Pharmaceutical Sciences Assiut University, 17(1), pp. 73-79. doi: 10.21608/bfsa.1994.69790
VANCOUVER
El-Harras, S., Shawky, S., Hafez, E., Shaker, S. PHARMACEUTICAL AND HISTOLOGICAL STUDIES OF NEW SOLUBLE DIAZEPAM. Bulletin of Pharmaceutical Sciences Assiut University, 1994; 17(1): 73-79. doi: 10.21608/bfsa.1994.69790
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