FORMULATION OF OILY DRUGS IN POWDER FORM USING POROUS SILICAS I. VITAMIN E

Document Type : Original Article

Authors

1 Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

2 Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoicho, Chiba 263, Japan

Abstract

Porous calcium silicate (florite R) and controlled pore glass (CPG 75 & CPG 500) were investigated as carriers to formulate vitamin E in a free flowing powder form. The prepared dispersions were subjected to thermogravemetric analysis (TG), scanning electron microscopic examination, testing of flow ability, uniformity of content and in-vitro release of vitamin E.
TG of vitamin E - porous silicas. dispersions indicated that vitamin E existed in both lightly and strongly bound state. The latter was directly related to the specific surface area of the carrier. Florite R was found to have a greater ability to hold vitamin E than controlled pore glass. the dispersions prepared using florite R and containing up to 40% w/w vitamin E showed good flowability, uniformity of content and almost 100% release of the loaded drug.