EFFECTS OF POROUS SILICA AS DRUG CARRIER ON THE FORMULATION OF EFFERVESCENT NYSTATIN VAGINAL TABLETS

Safwat, S. M.; Ali, A. S.; Abdel-Sabour, I.

doi:10.21608/bfsa.1994.69800

EFFECTS OF POROUS SILICA AS DRUG CARRIER ON THE FORMULATION OF EFFERVESCENT NYSTATIN VAGINAL TABLETS

Document Type : Original Article

Authors

¹ Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

² Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

³ Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

10.21608/bfsa.1994.69800

Abstract

Nystatin was loaded into porous silica by solvent deposition technique. The physical and loaded drug mixtures were examined by DSC and powder X-ray diffractometry. The stability of the drug at different relative humidities at 25° in these systems was evaluated measuring the antimycotic effectiveness. The in-vitro dissolution of the drug from loaded mixtures was studied. The loaded mixtures were formulated into effervescent vaginal tablets. Physical characteristics and dissolution behavior of the prepared effervescent vaginal tablets were evaluated according to B.P. 1993 limits. DSC and powder X-ray diffraction results revealed that the drug was changed from crystalline to amorphous state depending on drug to carrier ratio. The drug was stable and retained its activity in loaded mixtures stored at 0 % relative humidity for 2 months at 25°. Transformation of the drug to the amorphous state in the loaded mixtures lead to enhancement of drug dissolution. The prepared effervescent vaginal tablets complied with the standard requirements of uniformity of weight, drug content, disintegration time, dissolution, hardness and friability tests.