EFFECT OF FORMULATION VARIABLES OF MULTIPLE EMULSION ON THE STABILITY AND ANTITREMOR ACTIVITY OF CHLORPHENOXAMINE HYDROCHLORIDE

Safwat, S. M.; Samy, I. M.; Abdel-Rahman, M.

doi:10.21608/bfsa.1994.69802

EFFECT OF FORMULATION VARIABLES OF MULTIPLE EMULSION ON THE STABILITY AND ANTITREMOR ACTIVITY OF CHLORPHENOXAMINE HYDROCHLORIDE

Document Type : Original Article

Authors

¹ Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

² Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

³ Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

10.21608/bfsa.1994.69802

Abstract

W/O/W multiple emulsion formulations of chlorphenoxamine hydrochloride were prepared. The results of dissolution indicate that the release of the drug from w/o/w multiple emulsion was significantly sustained.. The incorporation of the additives into the external aqueous phase of w/o/w multiple emulsions based on liquid paraffin increased the release of the drug in the following order: sodium chloride >' Polyvinyl alcohol > hydroxypropyl methylcellulose > polyvinylpyrrolidone. Stability studies of differentemulsion samples were conducted at various temperatures and, evaluated by using the conductivity method. The obtained data indicated that the emulsions were stable during the storage for 3 months at 25°C. The formula (F_m) of the multiple emulsion which contained castor oil with Span 60 possessed a more efficient prolonged antitremor effect and lowered of spontaneous locomotor activity (SLMA) in mice than that of the drug solution. The statistical analysis also revealed that this formula produced a greater sedative effect compared with that of the drug solution.