EVALUATION OF IBUPROFEN-CELLULOSIC POLYMERS SUSTAINED RELEASE TABLETS

Abdel Rahman, Aly A.; Aboutaleb, A. E.; Stamm, A.; Abdel Rahman, S. I.; Samy, E. M.

doi:10.21608/bfsa.1993.70026

EVALUATION OF IBUPROFEN-CELLULOSIC POLYMERS SUSTAINED RELEASE TABLETS

Document Type : Original Article

Authors

¹ Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

² Faculty of Pharmacy, Louis Pasteur University, France

10.21608/bfsa.1993.70026

Abstract

Ibuprofen sustained release tabletse were formulated using wet granulation technique and cellulosic polymers as granulating agents including ethyl cellulose 20, hydroxypropyl methyl cellulose (pharmacoat 606) and hydroxypropyl methyl cellulose phthalate (HP 55 F).
The effect of tablet excipients including Avicel PH 102, Lactose, Emcompress and Emedex on the release rate of ibuprofen from the prepared tablets was also investigated using shift dissolution method.
It was found that among the formulated ibuprofen sustained release tablets, those tablets granulated with 3% w/v ethyl cellulose 20 and containing 23% Emcompress as an excipient were proved to be superior for ibuprofen sustained release. Higher Avicel PH 102 concentration (39 and 40% w/w) was found to enhance the release.
Comparing the effect of 1% w/v of the investigated cellulosic polymers on ibuprofen retardation, it was found to be in the following order: ethyl cellulose 20 > HP 55 F > pharmacoat 606.
Various kinetic models including zero order, first order and Higuchi equation were applied to explain the release mechanism from the prepared tablets. It was found that the best fit with the highest correlation coefficient was achieved with the zero-order equation.