THE MODE OF INCLUSION COMPLEXATION OF BROMAZEPAM WITH DIMETHYL -CYCLODEXTRIN

Saleh, S. I.; Abdel-Rahman, Aly A.; Aboutaleb, A. E.; Nakai, Y.; Ahmed, M. O.

doi:10.21608/bfsa.1993.70028

THE MODE OF INCLUSION COMPLEXATION OF BROMAZEPAM WITH DIMETHYL -CYCLODEXTRIN

Document Type : Original Article

Authors

¹ Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

² Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan

10.21608/bfsa.1993.70028

Abstract

Inclusion complex formation of bromazepam with heptakis- (2 ,6-di-O-methyl)-b-cyclodextrin (DM-b-CD) in aqueous solution was confirmed by the solubility method. A_L-type phase solubility diagram was obtained with 50 folds increase in the solubility of bromazepam. Crystalline inclusion complexes of bromazepam with DM-b-CD in 1 : 1 and 1 : 2 molar ratios were obtained by the co-precipitation method as indicated by the X-ray diffraction analysis. Infrared (IR) spectra of the inclusion complex ,of bromazepam and DM-b-CD was different depending on the molar ratio, whether it is 1: 1 or 1 : 2. In the same time, the differential scanning calorimetry (DSC) analysis showed different thermal behaviour depending on the molar ratio of the inclusion complex. These results revealed that the mode of molecular interaction of 1 : 1 inclusion complex of bromazepam with DM-b-CD was different from that of 1 : 2.