Rapid third derivative (D) spectrophotometric analysis procedures are described for the determination of aminoglutethimide and its N-acetyl metabolite in human plasma. The developed procedures minimize the mutual interference between these compounds and allow their determination without a previous extraction step. Aminoglutethimide and N-acetylaminoglutethimide are determined through the measurement of D3 amplitudes at 266 and 256 nm, respectively. Relative standard deviations for the assay of both compounds were less than 1.24%. Recoveries ranged from 97.2 to 99.8% for aminoglutethimide and from 97.0 to 99.4% for N-acetylaminoglutethimide.
Abdel-Khalek, M., Mahrous, M., Daabees, H., & Beltagy, Y. (1993). A THIRD DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR THE IN VITRO DETERMINATION OF AMINOGLUTETHIMIDE AND ITS N-ACETYL METABOLITE IN HUMAN PLASMA. Bulletin of Pharmaceutical Sciences Assiut University, 16(2), 163-168. doi: 10.21608/bfsa.1993.70203
MLA
M. M. Abdel-Khalek; M. S. Mahrous; H. G. Daabees; Y. A. Beltagy. "A THIRD DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR THE IN VITRO DETERMINATION OF AMINOGLUTETHIMIDE AND ITS N-ACETYL METABOLITE IN HUMAN PLASMA", Bulletin of Pharmaceutical Sciences Assiut University, 16, 2, 1993, 163-168. doi: 10.21608/bfsa.1993.70203
HARVARD
Abdel-Khalek, M., Mahrous, M., Daabees, H., Beltagy, Y. (1993). 'A THIRD DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR THE IN VITRO DETERMINATION OF AMINOGLUTETHIMIDE AND ITS N-ACETYL METABOLITE IN HUMAN PLASMA', Bulletin of Pharmaceutical Sciences Assiut University, 16(2), pp. 163-168. doi: 10.21608/bfsa.1993.70203
VANCOUVER
Abdel-Khalek, M., Mahrous, M., Daabees, H., Beltagy, Y. A THIRD DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR THE IN VITRO DETERMINATION OF AMINOGLUTETHIMIDE AND ITS N-ACETYL METABOLITE IN HUMAN PLASMA. Bulletin of Pharmaceutical Sciences Assiut University, 1993; 16(2): 163-168. doi: 10.21608/bfsa.1993.70203
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