SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL THIOLS USING 2,6-DICHLOROQUINONE-4-CHLORIMIDE: PART II QUANTITATIVE RELATIONS BETWEEN MOLAR ABSORPTIVITIES AND MOLECULAR CONNECTIVITY INDEXES

Document Type : Original Article

Authors

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

Spectrophotometric determination of some pharmaceutical thiols using 2,6-dichloroquinone-4-chlorimide (DQC) at pH 7-8, has been previously reported. Correlation of €max or log €max with third-order valence molecular connectivity indexes of all the investigated compounds was found to be statistically highly significant. Correlation equations were used to predict the molar absorptivity of the interaction products of thiols with DQC.