SPECTROCOLOURIMETRIC DETERMINATION OF FURANOCHROMONES AND FURANOCOUMARINS IN PHARMACEUTICAL PREPARATIONS

Document Type : Original Article

Authors

Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt

Abstract

A colourimetric method based on the reaction of khellin, visnagin and ammidin (imperatorin) with aromatic aldhydes in acid media was developed. The colour obtained was used for the determination of ammidin and furanochromones in pharmaceutical preparations. The optimum conditions for colour production and stability were determined, Beer's Lambert's law was obeyed over the concentration range of 4-10 mcg/ml of each of khellin and visnagin and 4-60 mcg/ml for ammidin. The proposed method compared favourably with other reported methods.