SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN IMIDAZO[4,5-b]PYRIDINES

Document Type : Original Article

Authors

1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

2 School of Pharmacy, Temple University, Philadelphia, USA

Abstract

The synthesis of certain imidazo[4,5-b]pyridine derivatives namely;3-(p-(un)substitutedphenacyl) imidazo[4,5-b]pyridin-2-ones, their ketoximes and 1,3-bis(p-(un)substitutedphenacyl)imidazo[4,5-b]pyridin-2-ones, were under-taken. In addition the synthesis of a series of 2-methylaminoimidazo[4,5-b]pyridines and their corresponding ketoximes are discussed. Some of the synthesized imidazo[4,5-b]-pyridin-2-ones derivatives showed reasonable analgesic activity in comparison to Aspirin and Indomethacin. Compounds of 2-methylaminoimidazo [4,5-b] pyridines and their corresponding ketoximes have been tested for their anthelmintic activity against Ascaris Vitulorum of cattle in comparison to Mebendazole.