The reaction of 8-hydroxyquinoline I with epichlorohydrin in the presence of potassium carbonate yielded a mixture of the epoxide II and the chlorohydrin III. The reaction of certain amines with a mixture of II and III afforded 8-[2-hydroxy-3-(substitutedamino) propoxy] quinoline IVa-h. The structure of the synthesized compounds was established by microanalyses and 1H-NMR spectra. The hydrolytic rate constants in aqueous solution at pH 7 and pH 12 were determined using HPLC technique.
Ahmed, A. H. (1992). SYNTHESIS OF CERTAIN 8-[2-HYDROXY-3-(SUBSTITUTEDAMINO)PROPOXY]QUINOLINES AS B-ADRENERGIC BLOCKING AGENTS. Bulletin of Pharmaceutical Sciences Assiut University, 15(1), 83-88. doi: 10.21608/bfsa.1992.70218
MLA
Abd-El Hamid N. Ahmed. "SYNTHESIS OF CERTAIN 8-[2-HYDROXY-3-(SUBSTITUTEDAMINO)PROPOXY]QUINOLINES AS B-ADRENERGIC BLOCKING AGENTS", Bulletin of Pharmaceutical Sciences Assiut University, 15, 1, 1992, 83-88. doi: 10.21608/bfsa.1992.70218
HARVARD
Ahmed, A. H. (1992). 'SYNTHESIS OF CERTAIN 8-[2-HYDROXY-3-(SUBSTITUTEDAMINO)PROPOXY]QUINOLINES AS B-ADRENERGIC BLOCKING AGENTS', Bulletin of Pharmaceutical Sciences Assiut University, 15(1), pp. 83-88. doi: 10.21608/bfsa.1992.70218
VANCOUVER
Ahmed, A. H. SYNTHESIS OF CERTAIN 8-[2-HYDROXY-3-(SUBSTITUTEDAMINO)PROPOXY]QUINOLINES AS B-ADRENERGIC BLOCKING AGENTS. Bulletin of Pharmaceutical Sciences Assiut University, 1992; 15(1): 83-88. doi: 10.21608/bfsa.1992.70218
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