THE USE OF HPLC-CYCLOBOND COLUMN FOR QUANTITATIVE DETERMINATION OF ANTICATARRHAL TABLETS

El-Gizawy, S. M.; Ahmed, A. N.; Makboul, M. A.

doi:10.21608/bfsa.1991.70369

THE USE OF HPLC-CYCLOBOND COLUMN FOR QUANTITATIVE DETERMINATION OF ANTICATARRHAL TABLETS

Document Type : Original Article

Authors

¹ Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Assiut University, Assiut, Egypt

² Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy Assiut University, Assiut, Egypt

³ Department of Pharmacognosy, Faculty of Pharmacy Assiut University, Assiut, Egypt

10.21608/bfsa.1991.70369

Abstract

The utility of high performance liquid chromatography cyclobond-I column for the separation and analysis of paracetamol, phenylpropanolamine HCl and chlorpheniramine maleate in synthetic mixture was clearly demonstrated using mobile-phase methanol: phosphate buffer pH 7.0 (10:90), flow rate 0.8 ml min^-1 and the detection was affected spectrophotometrically at 254 nm. Adequate sensitivity and an excellent' precision were obtained for the determination of the commercial dosage form.