STUDY OF THE EFFECT OF VERAPAMIL, CHLORDIAZEPOXIDE AND THEIR COMBINATION ON SPONTANEOUS LOCOMOTOR ACTIVITY IN MICE

Abdel-Rahman, M. M.

doi:10.21608/bfsa.1991.70372

STUDY OF THE EFFECT OF VERAPAMIL, CHLORDIAZEPOXIDE AND THEIR COMBINATION ON SPONTANEOUS LOCOMOTOR ACTIVITY IN MICE

Document Type : Original Article

Author

M. M. Abdel-Rahman

Department of Pharmacology, Faculty of Medicine, Assiut university, Assiut, Egypt

10.21608/bfsa.1991.70372

Abstract

The effects of verapamil, ch1ordiazepoxide (CDX) separately or and in combination on spontaneous locomotor activity (SLMA) of mice were investigated using an activity cage apparatus. Results of the present study revealed that the i.p. injection of verapamil in three dose levels(0.3, 0.6 and 1.3 mg/kg) elicited a dose dependent decrease, both in intensity and duration, of SLMA of mice. The i.p. administration of CDX in doses of 5 and 10 mg/kg brought about a significant dose-related diminution of SLMA of mice. Verapamil, in its three levels, administered concurrently with CDX., in its two dose levels, resulted in a significant potentiation of CDX- induced inhibition of SLMA. However, This potentiation caused by verapamil was much more evident with the smaller dose level of CDX (5mg/kg), than with the higher dose level (10 mg/kg).
Available reports are in agreement with our results. These reports indicate that verapamil might have the ability to suppress ALMA of mice'· and to potentiate the CDX-induced inhibition of SLMA via different mode of action.