DESIGN OF SUSTAINED RELEASE FORMULATIONS OF SALBUTAMOL I- ION-EXCHANGE RESIN SYSTEMS

Sayed, H. Abdel Monem; El-Sayed, A. M.; Osman, A. Hamed; Fathy, M.

doi:10.21608/bfsa.1991.70374

DESIGN OF SUSTAINED RELEASE FORMULATIONS OF SALBUTAMOL I- ION-EXCHANGE RESIN SYSTEMS

Document Type : Original Article

Authors

¹ Department of Pharmaceutics., Faculty of Pharmacy, Assiut University, Assiut, Egypt

² Department of Chest, Faculty of Medicine, Assiut University, Assiut, Egypt

10.21608/bfsa.1991.70374

Abstract

Ion-exchange resins were used in an attempt to prepare sustained release products of salbutamol. Different types of cation-exchange resins were tested namely; Amberlite IRP-69, Amberlite IR-120, Amberlite MB-l, Amberlite CG-50 and Amberlite IRC-50. The drug was loaded onto resins using the batch process. The effect of drug concentration and the resin forms on the loading capacity of resins were tested. The drug release patterns from its resinates were studied. The release rates were too high to bring about sustained action properties. The drug resinates prepared by the use of each Amberlite IRP-69 (H⁺ and Na⁺- form) and Amberlite IR-120 (Na⁺-form) were subjected to coating treatment adopting emulsion-solvent evaporation microencapsulation. Cellulose acetate butyrate was used as the coating material, A sustained release formulations of the prepared· microcapsules were clinically evaluated. The treatment with the sustained release formulation given twice daily was found to be clinically the same or better than of the plain drug given three times a day.