The interaction between temazepam and b-cyclodextrin (b-CD) or hydroxypropyl b-cyclodextrin (HPb-CD) was studied in aqueous solution. The attempts made to obtain temazepam-cyclodextrin complexes in the solid state through freeze drying or slow evaporation under nitrogen of equimolar solutions of temazepam-CD failed to separate these inclusion compounds. On the other hand, co-grinding of temazepam with b-CD or HPb-CD although showed no evidence of formation of inclusion complexes, yet gave rise to very fast dissolution compared to non-treated temazepam or its physical mixtures with CD. Furthermore, the co-grinding of temazepam with Avicel PH 101 (microcrystalline ,cellulose) improved temazepam dissolution to nearly the same extent as those of b-CD or HPb- CD.
Saleh, S., Ahmed, S., & Aiache, J. (1991). IMPROVEMENT OF DISSOLUTION BEHAVIOR OF TEMAZEPAM. Bulletin of Pharmaceutical Sciences Assiut University, 14(1), 95-102. doi: 10.21608/bfsa.1991.70378
MLA
S. I. Saleh; S. M. Ahmed; J. M. Aiache. "IMPROVEMENT OF DISSOLUTION BEHAVIOR OF TEMAZEPAM". Bulletin of Pharmaceutical Sciences Assiut University, 14, 1, 1991, 95-102. doi: 10.21608/bfsa.1991.70378
HARVARD
Saleh, S., Ahmed, S., Aiache, J. (1991). 'IMPROVEMENT OF DISSOLUTION BEHAVIOR OF TEMAZEPAM', Bulletin of Pharmaceutical Sciences Assiut University, 14(1), pp. 95-102. doi: 10.21608/bfsa.1991.70378
VANCOUVER
Saleh, S., Ahmed, S., Aiache, J. IMPROVEMENT OF DISSOLUTION BEHAVIOR OF TEMAZEPAM. Bulletin of Pharmaceutical Sciences Assiut University, 1991; 14(1): 95-102. doi: 10.21608/bfsa.1991.70378
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