Rifampicin is a powerful bactericidal antitubercular drug. The drug was formulated as suppositories. Witepsol H12 was used as the formulating base. Certain other bases as witepsol H15 and W35 and Massa estarinum B and BC as well as cacao butter replaced witepsol H12. Non-ionic surfactants with different chemical compositions, different HLB values as well as different physical and solubility properties were incorporated into witepsol H12 at 5% concentration, of the tested surfactants were polysorbates. Spans, Myrjs and Brijs. Drug dialysis into saline solution at 37°C was studied through cellophane membrane, of the tested bases. Witepsols gave the highest dialysis rates. Polysorbates proved to be superior among the tested surfactants.
Sayed, H., Ismail, S., & Mohamed, A. (1990). FORMULATION OF RIFAMPICIN SUPPOSITORIES. Bulletin of Pharmaceutical Sciences Assiut University, 13(1), 97-102. doi: 10.21608/bfsa.1990.70551
MLA
H. Abdel-Monem Sayed; S. Ismail; A. A. Mohamed. "FORMULATION OF RIFAMPICIN SUPPOSITORIES". Bulletin of Pharmaceutical Sciences Assiut University, 13, 1, 1990, 97-102. doi: 10.21608/bfsa.1990.70551
HARVARD
Sayed, H., Ismail, S., Mohamed, A. (1990). 'FORMULATION OF RIFAMPICIN SUPPOSITORIES', Bulletin of Pharmaceutical Sciences Assiut University, 13(1), pp. 97-102. doi: 10.21608/bfsa.1990.70551
VANCOUVER
Sayed, H., Ismail, S., Mohamed, A. FORMULATION OF RIFAMPICIN SUPPOSITORIES. Bulletin of Pharmaceutical Sciences Assiut University, 1990; 13(1): 97-102. doi: 10.21608/bfsa.1990.70551
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