Positional isomers of dimethyl pyrazole carboxylic acid derivatives were prepared. Some of these compounds showed variable binding capacities towards Cu (II), Zn (II) and Mg (II). The most active chelators Ig and its isomer IIg showed antidotal and antiinflammatory activities higher than D-penicillamine. Both are more active in dose levels much lesser than their median lethal doses (LD50). 5(3)-Methylpyrazole-3(5)-carboxamide showed significant growth inhibition of R. solani. The other derivatives tested displayed growth stimulating activity rather than growth inhibition of the fungus.
Fadl, T., Youssef, A., Ahmed, A., & El-Bitar, H. (1990). SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES. Bulletin of Pharmaceutical Sciences Assiut University, 13(2), 145-158. doi: 10.21608/bfsa.1990.70559
MLA
Tarek A. Fadl; Adel F. Youssef; Abdel-Hamed N. Ahmed; Hussein I. El-Bitar. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES". Bulletin of Pharmaceutical Sciences Assiut University, 13, 2, 1990, 145-158. doi: 10.21608/bfsa.1990.70559
HARVARD
Fadl, T., Youssef, A., Ahmed, A., El-Bitar, H. (1990). 'SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES', Bulletin of Pharmaceutical Sciences Assiut University, 13(2), pp. 145-158. doi: 10.21608/bfsa.1990.70559
VANCOUVER
Fadl, T., Youssef, A., Ahmed, A., El-Bitar, H. SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN 1,3-AND 1,5-DIMETHYL-N-SUBSTITUTED PYRAZOLE CARBOXAMIDES. Bulletin of Pharmaceutical Sciences Assiut University, 1990; 13(2): 145-158. doi: 10.21608/bfsa.1990.70559
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