Aspirin microcapsules were prepared by the solvent evaporation method. Ethylcellulose was used as the coating material at 18:2, 17:3 and 16:4 core : coat ratios. The prepared microcapsules were separated into sieve fractions. Each fraction was evaluated for drug content and dissolution characteristics. Scaling-up was developed to evaluate the adopted microencapsulation method for large scale production. The adopted method was simple, efficient and reproducible. A prolonged release pattern of the drug was obtained by increasing the coat/core ratio. Larger microcapsules released aspirin at a slower rate than did smaller microcapsules. Scaling-up did not significantly affect the release characteristics of drug from the prepared microcapsules. Histological studies on the Guinea pig gastric mucosa after the oral administration of encapsulated aspirin revealed a lower incidence of this product compared to unencapsulated drug.
Ibrahim, S., Sayed, H., Hafez, E., El-Sayed, A., & Ali, S. (1990). PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN. Bulletin of Pharmaceutical Sciences Assiut University, 13(2), 235-246. doi: 10.21608/bfsa.1990.70581
MLA
S. A. Ibrahim; H. A. Sayed; E. Hafez; A. M. El-Sayed; S. S. Ali. "PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN". Bulletin of Pharmaceutical Sciences Assiut University, 13, 2, 1990, 235-246. doi: 10.21608/bfsa.1990.70581
HARVARD
Ibrahim, S., Sayed, H., Hafez, E., El-Sayed, A., Ali, S. (1990). 'PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN', Bulletin of Pharmaceutical Sciences Assiut University, 13(2), pp. 235-246. doi: 10.21608/bfsa.1990.70581
VANCOUVER
Ibrahim, S., Sayed, H., Hafez, E., El-Sayed, A., Ali, S. PREPARATION AND EVALUATION OF SUSTAINED RELEASE ETHYLCELLULOSE ENCAPSULATED ASPIRIN. Bulletin of Pharmaceutical Sciences Assiut University, 1990; 13(2): 235-246. doi: 10.21608/bfsa.1990.70581
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