INTERACTIONS OF RIBOFLAVINE WITH CERTAIN ANALGESICS

Document Type : Original Article

Authors

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

The interaction of riboflavine with certain analgesics viz, paracetamol, phenazine, aspirin and acetanilide was investigated. The solubility of riboflavine was increased linearly with increasing the concentration of both paracetamol and phenazone. Aspirin and acetanilide however showed no effect on the solubility of riboflavine. The apparent partition coefficient of riboflavine between chloroform and water was decreased to variable extents in the presence of different molar ratios of riboflavine and of the tested analgesics. The diffusion rate f riboflavine through cellophane membrane was enhanced in presence of paracetamol followed in decreasing order by aspirin and phenazone. However, acetanilide, showed no increasing effect on the diffusion rate of riboflavine. The presence of these analgesics showed marked changes in the UV and IR absorption spectra of riboflavine. The Job's method of continuous variation was adopted to investigate these interactions and complexes of 1:1 molar ratio were revealed between riboflavine and each of paracetamol, aspirin and phenazone. It could be concluded that complexation between riboflavine (a very slightly soluble drug in water) and the commonly used analgesics viz., paracetamol, aspirin and phenazone led to changes in the solubility, partition and diffusion rate of the vitamin which in turn could affect its absorption and availability. 

Files

Share

How to cite

Statistics