QUANTITATIVE MOLAR ABSORPTIVITY-STRUCTURE RELATIONSHIPS OF CERTAIN CATECHOLAMINES

Authors

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

Molar absorptivities of six catecholamines (CA) are determined from their reactions with hydrochloric acid, boric acid molybdic acid, germanium dioxide, iron (II)-citrate and zirconyl chloride. Significant linear correlations are obtained between emax and the number of ligands. emax of most of the (CA) investigated shows a significant correlation with the molecular connectivity indices of the side chains and pka values. A dimeric state is suggested for (CA) in 0.1 N hydrochloric acid medium.