Chlordiazepoxide hydrochloride (CDZ); is formulated in different suppository bases. Its in vitro release from these selected suppository bases was studied and found to be base dependent. The effect of drug concentration was also studied. The percentage of drug diffused, through cellophane membrane, increased with decreasing the drug concentration. Drug particle size was found to have an insignificant effect on the release rate. Histological studies of the rabbit rectal mucosa after the rectal insertion of the tested suppository bases either alone or in the presence of CDZ showed insignificant histological changes.
Habib, F., Sayed, H., Ismail, S., Shaker, S., & Shaker, A. (1987). FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES. Bulletin of Pharmaceutical Sciences Assiut University, 10(1), 123-145. doi: 10.21608/bfsa.1987.74050
MLA
F. S. Habib; H. A. Sayed; S. Ismail; S. Shaker; A. Shaker. "FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES". Bulletin of Pharmaceutical Sciences Assiut University, 10, 1, 1987, 123-145. doi: 10.21608/bfsa.1987.74050
HARVARD
Habib, F., Sayed, H., Ismail, S., Shaker, S., Shaker, A. (1987). 'FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES', Bulletin of Pharmaceutical Sciences Assiut University, 10(1), pp. 123-145. doi: 10.21608/bfsa.1987.74050
VANCOUVER
Habib, F., Sayed, H., Ismail, S., Shaker, S., Shaker, A. FORMULATION AND EVALUATION OF DIFFERENT CHLORDIAZEPOXIDE HYDROCHLORIDE SUPPOSITORIES. Bulletin of Pharmaceutical Sciences Assiut University, 1987; 10(1): 123-145. doi: 10.21608/bfsa.1987.74050
)
View on SCiNiTO