A selective spectrophotometric method is developed for the quantitative determination of levodopa. The proposed method is based on the interaction of levodopa with thiosemicarbazide in an alkaline medium to form a red coloured product. At the maximum absorption of 500 nm, Beer's law is adhered to over the 0-5-8 mg/ml range. Mglar absorptivity of the coloured product is 2.58 x 104. Job's indicates 1:2 ratio of levodopa to thiosemicarbazide. Resulrs of analysis of larodopa tablets by the proposed method agree well with those of U.S.P.XXI. The method is highly selective since a catecholic function with free adjacent positions is required.
El-Kommos, M. (1987). SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA. Bulletin of Pharmaceutical Sciences Assiut University, 10(2), 34-46. doi: 10.21608/bfsa.1987.74394
MLA
M. E. El-Kommos. "SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA". Bulletin of Pharmaceutical Sciences Assiut University, 10, 2, 1987, 34-46. doi: 10.21608/bfsa.1987.74394
HARVARD
El-Kommos, M. (1987). 'SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA', Bulletin of Pharmaceutical Sciences Assiut University, 10(2), pp. 34-46. doi: 10.21608/bfsa.1987.74394
VANCOUVER
El-Kommos, M. SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF LEVODOPA. Bulletin of Pharmaceutical Sciences Assiut University, 1987; 10(2): 34-46. doi: 10.21608/bfsa.1987.74394
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