Seventeen drugs belonging to different pharmacological groupings have been determined either in pure form or in pharmaceutical formulations by spectrophotometry and spectrofluormetry. The method involves the condensation of malonic acid with acetic anhydride under the catalysis of a tertiary amine group in an aliphatic or a heterocyclic system. The product of condensation reaction is highly fluorescent and allows the spectrofluorometric determination of drug containing such groups in the ng/ml ranges (lex=415nm, lem=455 nm).The product of condensations also coloured and allows the spectrophotometric determination of these tertiary amine drugs (lmax=333nm). Results of analyses of pure drugs and their dosage forms by the proposed methods are in good agreement with those of the official B.P. and U.S.P. procedures.
Refaat, I., El-Kommos, M., Farag, H., & El-Rabat, N. (1987). SPECTROFLUOROMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF SOME TERTIARY AMINE DRUGS. Bulletin of Pharmaceutical Sciences Assiut University, 10(2), 85-102. doi: 10.21608/bfsa.1987.74398
MLA
I. H. Refaat; M. E. El-Kommos; H. H. Farag; N. A. El-Rabat. "SPECTROFLUOROMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF SOME TERTIARY AMINE DRUGS". Bulletin of Pharmaceutical Sciences Assiut University, 10, 2, 1987, 85-102. doi: 10.21608/bfsa.1987.74398
HARVARD
Refaat, I., El-Kommos, M., Farag, H., El-Rabat, N. (1987). 'SPECTROFLUOROMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF SOME TERTIARY AMINE DRUGS', Bulletin of Pharmaceutical Sciences Assiut University, 10(2), pp. 85-102. doi: 10.21608/bfsa.1987.74398
VANCOUVER
Refaat, I., El-Kommos, M., Farag, H., El-Rabat, N. SPECTROFLUOROMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF SOME TERTIARY AMINE DRUGS. Bulletin of Pharmaceutical Sciences Assiut University, 1987; 10(2): 85-102. doi: 10.21608/bfsa.1987.74398
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