COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS 3- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND CERTAIN PHYSICOCHEMICAL PARAMETERS OF RING SUBSTITUENTS

Document Type : Original Article

Authors

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

Abstract

The color intensity developed from the reaction of twelve phenothiazine drugs with I3 has been correlated using physicochemical substituent like Hammett constant sp, and molecular connectivity 1Xv. Results indicated a predominant role of electronic parameter in determining color intensity. The bulkiness described by 1Xv played a significant role. However, other parameters of the side chain were also prominent. Working up multiple parametric regression can be used as a reliable tool to predict the sensitivity and scope of the colorimetric method for other phenothiazines.