SYNTHESIS AND ANTIBACTERIAL TESTING OF SOME NEW SELENADIAZOLE AND THIADIAZOLE CONTAINING AMINO ACID MOIETIES

Bayoumi, B. E.; Abd-Alla, M. A.; Ahmed, A. N.

doi:10.21608/bfsa.1986.74575

SYNTHESIS AND ANTIBACTERIAL TESTING OF SOME NEW SELENADIAZOLE AND THIADIAZOLE CONTAINING AMINO ACID MOIETIES

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt

² Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

10.21608/bfsa.1986.74575

Abstract

Several 4-{4-(substitutedglycylamino)-phenyl}-1,2,3-selenadiazols (IV) and 4{4-(substitutedglycylamino)phenyl}-1,2,3-thiadiazoles (V) were prepared for evaluation of their antimicrobial activity. 4-chloroacetylaminoacetophenone (I) when reacted with different amines gave 4-glycylaminoacetophenone derivatives (II), Condensation of II with semicarbazide furnished the corresponding semicrabazones (III). Oxidative cyclization of (III) either by selenium dioxide or thionyl chloride afforded IV and V respectively.