SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME N-SUBSTITUTED-N'-(2-METHYL-4-OXOQUINAZOLIN-3-YL) OXAMIDES

Document Type : Original Article

Authors

1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

2 Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

Abstract

Fourteen new oxamides were synthesized by amidation of ethyl N-(2-methyl-4-oxoquinazolin-3-yl) oxamate with the appropriate amines. Preliminary anticonvulsant activity of five oxamides was evaluated, Correlation of activity with structure of the test compounds is also discussed.