Titrimetric and spectrophotometric determination methods are described for mebendazole and flubendazole in dosage forms. The first method depends upon addition of an excess of standard N-bromosuccinimide (NBS) and after the specified time, the residual reagent is determined iodometrically. This procedure permits semi-micro determination (3-30 mg) of the drug. An alternative procedure involves measurement of the colour produced after reaction with N-bromosuccinimide (lmax 465 nm). The stoichiometry of the reaction was studied and found 1:1 for mebendazole- NBS and 1:2 for flubendazole-NBS. The methods were applied successfully for the analysis of either of the two drugs in some formulations. Average recoveries ranging from 98.70±1.64 to 101.94±0.82 for titrimetric and from 97.5 ± 0.65 to 101.30± 0.55 for spectrophotometric methods were obtained. The methods were compared with U.S.P. XX method in case of mebendazole and were found in good agreement.
Mohamed, F., Sidhom, M., & Hussein, S. (1986). TITRIMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE AND FLUBENDAZOLE USING N-BROMOSUCCINIMIDE. Bulletin of Pharmaceutical Sciences Assiut University, 9(2), 92-104. doi: 10.21608/bfsa.1986.74580
MLA
F. A. Mohamed; M. B. Sidhom; S. A. Hussein. "TITRIMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE AND FLUBENDAZOLE USING N-BROMOSUCCINIMIDE". Bulletin of Pharmaceutical Sciences Assiut University, 9, 2, 1986, 92-104. doi: 10.21608/bfsa.1986.74580
HARVARD
Mohamed, F., Sidhom, M., Hussein, S. (1986). 'TITRIMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE AND FLUBENDAZOLE USING N-BROMOSUCCINIMIDE', Bulletin of Pharmaceutical Sciences Assiut University, 9(2), pp. 92-104. doi: 10.21608/bfsa.1986.74580
VANCOUVER
Mohamed, F., Sidhom, M., Hussein, S. TITRIMETRIC AND SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE AND FLUBENDAZOLE USING N-BROMOSUCCINIMIDE. Bulletin of Pharmaceutical Sciences Assiut University, 1986; 9(2): 92-104. doi: 10.21608/bfsa.1986.74580
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