SYNTHESIS OF SOME 2,7-DIAZABICYCLO {4.l.0} HEPT-3-ENE DERIVATIVES WITH ANALGESIC AND ANTICOCCIDIAL ACTIVITY

Document Type : Original Article

Authors

1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

2 Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

3 Department of Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt

Abstract

The 1,3-dipolar cycloaddition reaction of arylsulphonyl azides to 1,3-disubstituted-1,4-dihydropyridines afforded 2,7-diazabieyclo {4.1.0} hept-3-ene derivatives (III).These compounds exhibited more significant analgesic and anticoccidial activities than aspirin and sulphaguanidine respectively.
Bulletin of Pharmaceutical Sciences Assiut University
Volume 9, Issue 2
December 1986
Pages 105-118

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