PREFORMULATION STUDIES ON DIRECTLY COMPRESSED TEMAZEPAM TABLETS

Document Type : Original Article

Authors

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

Temazepam, a benzodiazepine derivative, was prepared in directly compressed tablets using Avicel, Anhydrous Lactose (A.H.L.), STA-Rx 1500, Emcompress and Compactrol. It was found that A.H.L. represents the most suitable single vehicle while Avicel : STA-RX 1:1 blend was the most suitable blend for the preparation of temazepam tablets. STA-RX 1500 and its blends with the other used vehicles were shown to give the highest dissolution. The most uniform tablets were produced on using Emcompress alone or as a binary blend with Avicel (1:1) as directly compressible vehicles.