SPECTRODENSITOMETRIC DETERMINATION OF NICOTINAMIDE IN SOME MULTIVITAMIN PREPARATIONS

Ismaiel, S. A.; Haney, Jr., W. G.; Abdel-Moety, E. M.

doi:10.21608/bfsa.1985.75891

SPECTRODENSITOMETRIC DETERMINATION OF NICOTINAMIDE IN SOME MULTIVITAMIN PREPARATIONS

Document Type : Original Article

Authors

¹ Research Directorate Misr Company for Pharmaceutical Industries, El-Mataria, Cairo, Egypt

² School of Pharmacy, University of Missouri, Kansas-City, Rockhill Road, Kansas City, Missouri 64110, U.S.A.

³ Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr EI-Aini, Cairo, Egypt

10.21608/bfsa.1985.75891

Abstract

A sensitive, highly selective and stability indicating procedure for the determination of nicotinamide in some multi-vitamin preparations is described. The procedure is based on thin-layer chromatographic separation of nicotinamide from other constituents of the dosage form, the reaction with aniline and cyanogen bromide vapours, and spectrodensitometric determination at 468 nm. The method is suitable for content uniformity studies.