PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS

Nouh, A. T.; Kassem, M. A.A.; Kassem, Alaa A.; Elmahrouk, G.

doi:10.21608/bfsa.1984.89521

PROLONGATION OF THE RELEASE OF EPHEDRINE HYDROCHLORIDE BY THE USE OF ANIONIC ACRYLIC RESINS

Document Type : Original Article

Authors

¹ Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

² Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

³ Faculty of Pharmacy, El-Azhar University

10.21608/bfsa.1984.89521

Abstract

Eudragits S, L, RL and mixture of S and L were employed for prolonging the release of ephedrine hydrochloride from tablets by two different techniques, viz, spray coating and molecular dispersion. The in-vitro dissolution rate evaluation in both acid and alkaline media revealed that, tablets prepared with Eudragit-L showed the most prolonged release with t_20% of 3½ and 4½ hours for spray coating and molecular dispersion methods respectively. Concerning the technique itself; drug-Eudragit molecular dispersion system showed a slower release than spray coating.
Higuchi model for drug release could be applied for the release pattern only for few hours in case of tablets containing coated drug, while it absolutely explains the release from tablets having drug-Eudragit molecular dispersion system. Release was found to proceed according to order kinetics.