The effect of different hydroxylated compounds on the solubility of Methotrimeprazine in non-ionic surfactant solutions was investigated at two different temperatures. Ethanol, glycerol, polyethylene glycol (PEG) 600 and PEG 4000, mannitol and sorbitol were studied as additives in systems containing Eumulgin C 1000, Eumulgin C 1500, Brij 35 and Brij 58 as the solubilizing surfactants. Micellar solubilization of Methotrimeprazine was found to be increased in Brij 35 systems with all additives except at low concentration (5% w/v) of PEG 600. It also increased in systems of Brij 58 containing PEG 600, PEG 4000, mannitol and sorbitol. A marked decrease in micellar solubilization of the drug was effected in systems of Eumulgine and Brij-58 containing ethanol or glycerol due to decreased micellization. Also, PEG 4000, mannitol and sorbitol decreased solubilizing effect of Eumulgine, except for PEG 4000 with Eumulgin C1000 at 35°.
Aboutaleb, A., Mesiha, M., & Abdel-Zaher, A. (1984). EFFECT OF SOME HYDROXYLATED ADDITIVES ON THE MICELLAR SOLUBILIZATION OF METHOTRIMEPRAZINE. Bulletin of Pharmaceutical Sciences Assiut University, 7(1), 97-108. doi: 10.21608/bfsa.1984.89533
MLA
A. E. Aboutaleb; M. S. Mesiha; A. Abdel-Zaher. "EFFECT OF SOME HYDROXYLATED ADDITIVES ON THE MICELLAR SOLUBILIZATION OF METHOTRIMEPRAZINE". Bulletin of Pharmaceutical Sciences Assiut University, 7, 1, 1984, 97-108. doi: 10.21608/bfsa.1984.89533
HARVARD
Aboutaleb, A., Mesiha, M., Abdel-Zaher, A. (1984). 'EFFECT OF SOME HYDROXYLATED ADDITIVES ON THE MICELLAR SOLUBILIZATION OF METHOTRIMEPRAZINE', Bulletin of Pharmaceutical Sciences Assiut University, 7(1), pp. 97-108. doi: 10.21608/bfsa.1984.89533
VANCOUVER
Aboutaleb, A., Mesiha, M., Abdel-Zaher, A. EFFECT OF SOME HYDROXYLATED ADDITIVES ON THE MICELLAR SOLUBILIZATION OF METHOTRIMEPRAZINE. Bulletin of Pharmaceutical Sciences Assiut University, 1984; 7(1): 97-108. doi: 10.21608/bfsa.1984.89533
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