FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES PART II: Formulation and Characterization of Heptaminol Suppositories

Document Type : Original Article

Authors

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Abstract

Heptaminol base was formulated in four different suppository bases. The prepared suppositories were subjected to the usual quality-control tests, both when fresh and after shelf-storage for one year. The results of physical examination were so variable that a sharp conclusion to a preferred formula was not possible. However, studies of medicament dissolution revealed that quick and full-dose release of heptaminol was achieved from glycerogelatin-based suppositories. On the other hand, suppositories based with polyethylene glycols have shown a prolonged heptaminol dissolution rates.