EFFECT OF CERTAIN ADDITIVES ON THE DIFFUSION CHARACTERISTICS OF ASPIRIN, SALICYLAMIDE AND PHENACETIN THROUGH A CELLOPHANE MEMBRANE II. Effect of Aliphatic Acids and Polyethylene Glycol

Habib, F. S.; El-Sourady, H. A.; Mohamed, S. E.

doi:10.21608/bfsa.1984.89871

EFFECT OF CERTAIN ADDITIVES ON THE DIFFUSION CHARACTERISTICS OF ASPIRIN, SALICYLAMIDE AND PHENACETIN THROUGH A CELLOPHANE MEMBRANE II. Effect of Aliphatic Acids and Polyethylene Glycol

Document Type : Original Article

Authors

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

10.21608/bfsa.1984.89871

Abstract

A study has been carried out showing the effect of succinic, citric and tartaric acids, polyethylene glycols 1500, 2000, 4000 and 6000 on the diffusion rate of aspirin, salicylamide and phenacetin through a standard cellophane membrane. It was found that 2% w/v succinic acid was the most effective concentration of acid that increased the diffusion rate of aspirin. The incorporation of 3% w/v PEG 2000 or 6000 slightly increased aspirin diffusion rate. The effect of the previously mentioned aliphatic acid, urea and PEG 4000 or 6000 in the form of either solid dispersions or physical mixtures with the drug was also studied. It was found that succinic acid in all its tried concentrations increased the diffusion rate of aspirin.
Salicylamide diffusion rate slightly increased in presence of 3% w/v succinic acid, 2 and 3% w/v citric acid and 3% w/v tartaric acid. Salicylamidesuccinic acid solid dispersion slightly increased the diffusion rate of the drug while the other tested drug-carrier solid dispersions of physical mixtures retarded the diffusion rate of salicylamide.
3% w/v of each aliphatic acid tested and PEG 6000 increased the diffusion rate of phenacetin. The other tested concentrations of PEG(s) produced insignificant effect on the diffusion rate of the drug. Phenacetin-urea, PEG 4000 or 6000 solid dispersions markedly increased the diffusion rate of phenacetin.