INFLUENCE OF CELLULOSE AND ACETATE-BASED POLYMERS ON THE RELEASE OF CIPROFLOXACIN HCL FROM EXTENDED RELEASE MATRIX TABLETS PREPARED BY DIRECT COMPRESSION TECHNIQUE

Khalid, Rida; Nasiri, Muhammad Iqbal; Sarwar, Humera; Yasmin, Riffat; Zaheer, Kamran; Anwer, Sohail; Fatima, Anab

doi:10.21608/bfsa.2020.93530

INFLUENCE OF CELLULOSE AND ACETATE-BASED POLYMERS ON THE RELEASE OF CIPROFLOXACIN HCL FROM EXTENDED RELEASE MATRIX TABLETS PREPARED BY DIRECT COMPRESSION TECHNIQUE

Document Type : Original Article

Authors

¹ Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

² Department of Pharmaceutics, Hamdard Institute of Pharmaceutical Sciences, Hamdard University, Islamabad, Pakistan

³ Department of Pharmaceutics, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan

10.21608/bfsa.2020.93530

Abstract

The objectives of the current study were to investigate the influence of different types and concentration of polymers on release of ciprofloxacin HCl as well as to formulate an extended release tablets of ciprofloxacin hydrochloride by direct compression method. Twelve formulations (F1–F12) were manually designed using different proportions (10–30%) of Hydroxypropyl methylcellulose (HPMC), Ethylcellulose (EC) and Kollidon SR polymers. Avicel PH101, talc and magnesium stearate were used in a constant quantity of 2% in all the formulations. Multiple point dissolution was carried out in different media. Dissolution profiles indicated that formulations F1, F4, F8 and F11, extended the drug release up to 12 hrs, while, other formulations failed to retard the drug release up to desired period. DDSolver software was used to analyze the dissolution profile data for drug release kinetics such as first order, Zero-order, Korsmeyer–Peppas and Higuchi models. Drug polymers compatibility was assessed using Fourier Transformed Infrared (FTIR) spectroscopy. Selected formulations were placed in the stability chamber at accelerated temperature (40±2°C and RH 75±5%) for six months and re-evaluated after 3 and 6 months as per ICH guidelines. The present study accomplished that ethylcellulose alone or in combination with HPMC was found to be an excellent rate controlling agent for ciprofloxacin and may be used successfully to develop extended release tablet formulations.