Effect of natural polymers on the physicochemical properties and ulcerogenic activity of piroxicam

El-Faham, T. H.; Mahmoud, M.; Hassan, M. A.

doi:10.21608/bfsa.2000.66136

Effect of natural polymers on the physicochemical properties and ulcerogenic activity of piroxicam

Document Type : Original Article

Authors

¹ Department of Pharmaceutics, Faculty of Pharmacy and Department of Histology,Faculty of Medicine, Assiut University, Assiut 71526, Egypt

² Department of Pharmaceutics, Faculty of Pharmacy and Department of Histology

³ Department of Pharmaceutics, Faculty of Pharmacy and Department of Histology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt

10.21608/bfsa.2000.66136

Abstract

Piroxicam belongs to the class of acidic non-steroidal antiinflammatory drugs. Under the acidic conditions in which its absorption takes place, its low soly. and dissoln. rate has been well documented. The effect of natural polymers such as pectin, lecithin, sodium alginate and gelatin on the physicochem. properties of piroxicam has been studied. Dispersions of these polymers with the drug were prepd. in different wt. ratios by the kneading method. The dissoln. rate of the drug decreased in presence of all these polymers except gelatin. Gelatin showed enhancing influence on piroxicam dissoln. A slight increase in dissoln. was also obtained with 1:2 drug-pectin ratio. The soly. of piroxicam decreased in the presence of different concns. of either pectin or lecithin but increased in the presence of different concns. of gelatin and sodium alginate. The interaction of these polymers and piroxicam was traced by x-ray diffraction and IR spectroscopy. In addn., piroxicam-induced gastric lesions in rats, disappeared by dispersing the drug in gelatin. Histol. studies showed intact surface epithelium and fundic glands in case of piroxicam-gelatin dispersion. So, piroxicam-gelatin dispersed mixt. is recommended to increase the dissoln. of the drug and protect against ulcerogenic activity.