IN VITRO RELEASE OF DIAZEPAM FROM DIFFERENT SUPPOSITORY FORMULATIONS

Ismail, Sayed; El-Shanawany, Sohair

doi:10.21608/bfsa.1993.70027

IN VITRO RELEASE OF DIAZEPAM FROM DIFFERENT SUPPOSITORY FORMULATIONS

Authors

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

10.21608/bfsa.1993.70027

Abstract

The effect of suppository vehicles, drug concentrations, liquid additives and some nonionic surfactants on the in vitro release of diazepam from different suppository formulation were investigated. The obtained data revealed that the drug release is significantly higher from suppository prepared using PEG than the other formulations. The drug release from oleaginous base was related inversely to its partition coefficient and the melting range of the tested oleaginous bases. The incorporation of 'some liquid additives (10%) was found to improve the release pattern of the drug from a PEG base. The degree) of improvement is correlated well to the solubility of the drug .in the utilized additives. The data, also, reveal that the release rate is directly proportional to the drug concentration. The incorporation of nonionic surfactants into Witepsol H₁₅ in a 5% concentration was found to increase the release rate of diazepam. The enhancing effect was found to be dependent on the chemical structure of the surfactants. The release rate of medicament from different solid nonionic surfactants, as suppository bases, was also studied. The magnitude of drug release was markedly reduced as compared with PEG bases.